Lab of immune-specificity mapping

Decoding the antigen-specific basis of human disease

Our lab studies the antigen-specific basis of T cell immunity. By precisely mapping which immune cells respond to which targets, a process called immune-specificity mapping, we uncover the molecular mechanisms underlying autoimmunity, cancer, and infectious disease. We combine cutting-edge tools including high-throughput genetic screens, single-cell profiling, and synthetic biology, applied to both human patient samples and preclinical animal models. Our goal is to translate this mechanistic understanding into next-generation therapies that target the immune system with precision, rather than suppressing or activating it broadly. Our mission is to move medicine closer to treatments that can truly cure or prevent disease.